Aptamer-based self-assembled nanomicelle enables efficient and targeted drug delivery
Ganghui Chen, Dongsheng Mao, Xuan Wang, Jingqi Chen, Chao Gu, Shuqin Huang, Yu Yang, Fang Zhang, Weihong Tan
Abstract
Abstract Nucleic acid aptamer-based nanomicelles have great potential for nanomedicine and nanotechnology applications. However, amphiphilic aptamer micelles are known to be inherently unstable upon interaction with cell membranes in the physiological environment, thus potentially compromising their specific targeting against cancer cells. This flaw is addressed in the present work which reports a superstable micellar nanodelivery system as an amphiphilic copolymer self-assembled micelle composed of nucleic acid aptamer and polyvalent hydrophobic poly(maleic anhydride-alt-1-octadecene) (C 18 PMH). Using Ce6 as a drug model, these C 18 -aptamer micelles exhibit efficient tumor-targeting and -binding ability, facilitating the entry of Ce6 into targeted cells for photodynamic therapy. In addition, they can be loaded with other hydrophobic drugs and still demonstrate favorable therapeutic effects. As such, these C 18 -aptamer micelles can serve as a universal platform for loading multiple drugs, providing a safer and more effective solution for treating cancer.