Ketamine and Electroconvulsive Therapy for Treatment-Refractory Depression
Xingbing Huang, Wei Zheng
Abstract
Major depressive disorder (MDD) is a highly incapacitating condition that has a significant impact on a large number of individuals worldwide, representing the greatest burden of disease among mental and neurological disorders. 1In China, MDD has been projected to be the second leading cause of years lived with disability. 2 Regrettably, over 30% of those who undergo major depressive episodes fail to attain antidepressant remission even after undergoing multiple attempts with antidepressants. 3This form of depression, known as treatmentresistant depression (TRD), is linked to premature mortality, including suicide. 4 In psychiatry, TRD represents a major challenge.
Topics & Concepts
Electroconvulsive therapyDepression (economics)KetamineRefractory (planetary science)Treatment-resistant depressionPsychotherapistPsychologyMedicinePsychiatryMajor depressive disorderSchizophrenia (object-oriented programming)EconomicsCognitionAstrobiologyPhysicsMacroeconomicsTreatment of Major DepressionElectroconvulsive Therapy StudiesTryptophan and brain disorders