Transition-metal-free trifluoromethylthiolation–acylation of arynes by insertion into the C–S bonds
Chengyao Kimmy Cao, E.V. Tretyakov, Chao Chen
Abstract
An efficient procedure to access to ortho-SCF3 substituted benzophenones from arynes and trifluoromethylthioesters has been developed under transition-metal free conditions. This difunctionalization process involves the first insertion of arynes into the C–S σ-bonds to achieve vicinal trifluoromethylthiolation-acylation of arenes in one step.
Topics & Concepts
AryneVicinalAcylationChemistryCombinatorial chemistryStereochemistryMedicinal chemistryOrganic chemistryCatalysisFluorine in Organic ChemistrySynthesis and Reactions of Organic CompoundsCyclization and Aryne Chemistry