Visible‐Light‐Induced Oxidative α‐Alkylation of Glycine Derivatives with Ethers under Metal‐Free Conditions
Yang Song, Haolan Zhang, Jiabao Guo, Yifei Shao, Yuzhou Ding, Li Zhu, Xiaoquan Yao
Abstract
Abstract In this work, a visible‐light‐induced oxidative α‐alkylation of glycine derivatives with ethers has been developed in the presence of catalytic Eosin Y. Under the blue light of a 3 W LED, a range of α‐etherized glycine derivatives, including α‐amino esters, α‐amino ketones and α‐amino amides, were achieved with good to excellent yields and functional group tolerance with tert ‐butyl hydroperoxide (TBHP) as oxidant at ambient temperature. The operationally easy procedure provides an economical, metal‐free, and mild alternative for the synthesis of the α‐etherized glycine derivatives.
Topics & Concepts
ChemistryAlkylationGlycineEosin YCatalysisFunctional groupOxidative phosphorylationOrganic chemistryAmino acidVisible spectrumCombinatorial chemistryPhotocatalysisBiochemistryOptoelectronicsPolymerPhysicsRadical Photochemical ReactionsSulfur-Based Synthesis TechniquesCatalytic C–H Functionalization Methods