Rhodium(III)‐Catalyzed Cross Coupling of Sulfoxonium Ylides and 1,3‐Diynes to Produce Naphthol‐Indole Derivatives: An Arene <i>ortho</i> C−H Activation/Annulation Cascade
Ruixing Liu, Yin Wei, Min Shi
Abstract
Abstract Synthesis of naphthol‐indoles starting from easily available 1,3‐diynes and sulfoxonium ylides via Rh III ‐catalyzed C−H activation/hydroamination cascade process in a one pot manner has been developed. The reaction proceeds through a Rh III ‐catalyzed arene ortho C−H activation and silver‐catalyzed hydroamination cascade to afford a variety of C2 position functionalized indoles in good yields with broad substrate scope and good functional group tolerance.
Topics & Concepts
HydroaminationRhodiumCatalysisChemistryAnnulationIndole testSubstrate (aquarium)CascadeCombinatorial chemistryCascade reactionStereochemistryMedicinal chemistryOrganic chemistryChromatographyGeologyOceanographyCatalytic C–H Functionalization MethodsCatalytic Alkyne ReactionsCyclopropane Reaction Mechanisms