Strategies to Combat Multi-Drug Resistance in Tuberculosis
Vinayak Singh, Kelly Chibale
Abstract
, for which MoA deconvolution studies revealed a pathway that explained the lack of in vivo efficacy in a mouse model of TB and reiterated the importance of selecting an appropriate growth medium during phenotypic screening. We also discuss our efforts on drug repositioning toward addressing DR-TB. In the concluding section, we preview some promising future directions and the challenges inherent in advancing the drug pipeline to address DR-TB.
Topics & Concepts
TuberculosisDrugDrug resistanceResistance (ecology)Intensive care medicineMedicineComputational biologyPharmacologyBiologyMicrobiologyPathologyEcologyTuberculosis Research and EpidemiologyPneumocystis jirovecii pneumonia detection and treatmentMycobacterium research and diagnosis