A Sleep‐Specific Midbrain Target for Sevoflurane Anesthesia
Tingting Yi, Na Wang, Jing Huang, Yaling Wang, Shuancheng Ren, Yiwen Hu, Jianxia Xia, Yixiang Liao, Xin Li, Fenlan Luo, Qin Ouyang, Yu Li, Ziyi Zheng, Qin Xiao, Rong Ren, Zhongxiang Yao, Xiangdong Tang, Yan‐Jiang Wang, Xiaowei Chen, Chao He, Hong Li, Zhian Hu
Abstract
Abstract Sevoflurane has been the most widely used inhaled anesthetics with a favorable recovery profile; however, the precise mechanisms underlying its anesthetic action are still not completely understood. Here the authors show that sevoflurane activates a cluster of urocortin 1 (UCN1 + )/cocaine‐ and amphetamine‐regulated transcript (CART + ) neurons in the midbrain involved in its anesthesia. Furthermore, growth hormone secretagogue receptor (GHSR) is highly enriched in sevoflurane‐activated UCN1 + /CART + cells and is necessary for sleep induction. Blockade of GHSR abolishes the excitatory effect of sevoflurane on UCN1 + /CART + neurons and attenuates its anesthetic effect. Collectively, their data suggest that anesthetic action of sevoflurane necessitates the GHSR activation in midbrain UCN1 + /CART + neurons, which provides a novel target including the nucleus and receptor in the field of anesthesia.