Off-the-Shelf Chimeric Antigen Receptor T Cells
Norihiro Watanabe, Maksim Mamonkin
Abstract
ABSTRACT: Banked chimeric antigen receptor (CAR) T cells immediately available for off-the-shelf (OTS) application can solve key limitations of patient-specific CAR T-cell products while retaining their potency. The allogeneic nature of OTS cell therapies requires additional measures to minimize graft-versus-host disease and host-versus-graft immune rejection in immunocompetent recipients. In this review, we discuss engineering and manufacturing strategies aimed at minimizing unwanted interactions between allogeneic CAR T cells and the host. Overcoming these limitations will improve safety and antitumor potency of OTS CAR T cells and facilitate their wider use in cancer therapy.
Topics & Concepts
Chimeric antigen receptorOff the shelfPotencyAntigenImmunotherapyImmune systemHost (biology)ImmunologyMedicineBiologyComputer scienceIn vitroGeneticsSoftware engineeringCAR-T cell therapy researchNanowire Synthesis and ApplicationsAdvancements in Semiconductor Devices and Circuit Design