Targeted delivery of thermoresponsive polymeric nanoparticle-encapsulated lycopene:<i>in vitro</i>anticancer activity and chemopreventive effect on murine skin inflammation and tumorigenesis
Sameena Bano, Faheem Ahmed, Farha Khan, Sandeep Chaudhary, Mohd Samim
Abstract
anticancer efficacy to free lycopene against the melanoma cell line B16. Furthermore, nanolycopene showed comparable reduction of TPA-induced skin edema, expression of COX-2, and oxidative stress response. Additionally, it showed significant inhibition of tumor promotion. It also altered Bax and Bcl2 expressions, which led to the induction of apoptosis. The results also supported that the extracted lycopene-encapsulated nanoparticles may be a good alternative to the expensive commercial lycopene for cancer treatment.
Topics & Concepts
LycopeneIn vitroCarcinogenesisInflammationChemistryNanoparticlePharmacologyCancer researchNanotechnologyBiochemistryMedicineMaterials scienceImmunologyAntioxidantGeneAntioxidant Activity and Oxidative StressPhytochemicals and Antioxidant ActivitiesRetinoids in leukemia and cellular processes