Pyrrolidine-based 3-deoxysphingosylphosphorylcholine analogs as possible candidates against neglected tropical diseases (NTDs): identification of hit compounds towards development of potential treatment of <i>Leishmania donovani</i>
Ahmed H.E. Hassan, Trong-Nhat Phan, Seolmin Yoon, Cheol Jung Lee, Hye Rim Jeon, Seunghwan Kim, Joo Hwan No, Yong Sup Lee
Abstract
as potential hit compounds for further development of new antileishmanial agents.
Topics & Concepts
EnantiomerPyrrolidineStereochemistryAmastigoteLeishmania donovaniIn silicoChemistryTrypanosoma bruceiHomology modelingMiltefosineBiochemistryBiologyLeishmaniaLeishmaniasisVisceral leishmaniasisEnzymeGeneticsComputer scienceWorld Wide WebParasite hostingGeneResearch on Leishmaniasis StudiesTrypanosoma species research and implicationsPhytochemistry and biological activities of Ficus species