Benzimidazole-1,2,3-triazole hybrid molecules: synthesis and study of their interaction with G-quadruplex DNA
Padma S. Singu, Ushasri Chilakamarthi, Namita S. Mahadik, Keerti Bhamidipati, Valipenta Narasimhulu, Santosh N. Mokale, Narayana Nagesh, Ravindra M. Kumbhare
Abstract
The benzimidazole-1,2,3-triazole hybrid <bold>4f</bold> selectively interacted with G-quadruplex DNA over duplex DNA, inhibits cell cycle at the G<sub>2</sub>/M phase, inducing apoptosis, and may be a G-quadruplex DNA groove binder with anticancer activity.
Topics & Concepts
DNAChemistryBenzimidazoleCytotoxicityTriazoleMoleculeFluorescenceFluorescence spectroscopyStereochemistryBiophysicsIn vitroBiochemistryBiologyOrganic chemistryQuantum mechanicsPhysicsDNA and Nucleic Acid ChemistryAdvanced biosensing and bioanalysis techniquesClick Chemistry and Applications