Increased expression of collagen prolyl hydroxylases in ovarian cancer is associated with cancer growth and metastasis.
Mihae Song, Erica Schnettler, Annapoorna Venkatachalam, Yujun Wang, Lisa Feldman, Peter A. Argenta, Lorna Rodrı́guez-Rodrı́guez, Sundaram Ramakrishnan
Abstract
. A2780 cells stably transfected with shP4HA1 and shP4HA2 inhibited tumor growth and metastases in athymic mice. Furthermore, our review of the TCGA dataset revealed that increased P4HA1 and P4HA2 mRNA levels are associated with decreased overall survival in patients with ovarian cancer. The increased expression of collagen P4HA has been linked to ovarian cancer growth and metastasis. This evidence highlights their potential as prognostic biomarkers and promising therapeutic targets.
Topics & Concepts
Gene knockdownMetastasisCancer researchOvarian cancerDownregulation and upregulationIn vivoExtracellular matrixCell growthCancerTransfectionCancer cellCell cultureIn vitroBiologyCTGFSmall hairpin RNAMedicineChemistryInternal medicineGrowth factorCell biologyGeneBiochemistryReceptorBiotechnologyGeneticsCancer, Hypoxia, and MetabolismMicrobial metabolism and enzyme functionCancer Research and Treatments