Simvastatin exerts neuroprotective effects post-stroke by ameliorating endoplasmic reticulum stress and regulating autophagy/apoptosis balance through pAMPK/LC3B/ LAMP2 axis
Bijoyani Ghosh, Aishika Datta, Vishal Gupta, Babasaheb Sodnar, Abhishek Sarkar, Upasna Singh, Swapnil Raut, Pramod Suthar, Vrushali Thongire, Deepaneeta Sarmah, Harpreet Kaur, Anupom Borah, Shailendra Saraf, Pallab Bhattacharya
Topics & Concepts
NeuroprotectionAutophagyMitophagyUnfolded protein responseEndoplasmic reticulumStatinSimvastatinMedicineDownregulation and upregulationApoptosisProgrammed cell deathPharmacologyParkinCell biologyInternal medicineChemistryBiologyBiochemistryGeneDiseaseParkinson's diseaseAutophagy in Disease and TherapyEndoplasmic Reticulum Stress and DiseaseCalpain Protease Function and Regulation