Metal-Free [3+2] Annulation of Ynamides with Anthranils to Construct 2-Aminoindoles
Jingyi Zhang, Ying Li, Chaofeng Zhang, Xiaona Wang, Junbiao Chang
Abstract
A novel metal-free [3+2] annulation of ynamides with anthranils provides a facile, flexible, environmentally friendly, and atom-economical route to 2-aminoindoles. This synthetic process proceeds with efficiency, excellent regioselectivity, and wide functional group tolerance under mild conditions. Moreover, the obtained 2-aminoindole products represent a multifunctional platform for the construction of various 2-aminoindolyl frameworks.
Topics & Concepts
AnnulationRegioselectivityChemistryEnvironmentally friendlyCombinatorial chemistryConstruct (python library)Atom (system on chip)MetalComputer scienceOrganic chemistryCatalysisParallel computingEcologyProgramming languageBiologyCatalytic Alkyne ReactionsCatalytic C–H Functionalization MethodsCyclopropane Reaction Mechanisms