Different Expression and Clinical Implications of Cancer-Associated Fibroblast (CAF) Markers in Brain Metastases
Md Rashedunnabi Akanda, Eun‐Jung Ahn, Yeong Jin Kim, S M Abdus Salam, Myung‐Giun Noh, Sung Sun Kim, Tae‐Young Jung, In‐Young Kim, Chang‐Hyun Kim, Kyung‐Hwa Lee, Kyung‐Sub Moon
Abstract
Our results suggest that high expression of CAF-related biomarkers, particularly PDGFR-β and α-SMA, is associated with poor prognosis and recurrence in patients with BM. With the elucidation of the role and origins of CAF in the tumor microenvironment, CAF can be a new imperative target for BM immunotherapy.
Topics & Concepts
Cancer-Associated FibroblastsImmunohistochemistryFibroblast activation protein, alphaPathologyStromal cellMetastasisMedicineCancer researchStromaTumor microenvironmentCancerCancer cellInternal medicineBrain Metastases and TreatmentLung Cancer Research StudiesGlioma Diagnosis and Treatment