Mechanism and stereoselectivity of a [3 + 2] cycloaddition involving a glucosyl nitrone: a MEDT study
Mohamed Chellegui, Simplice Koudjina, Ines Salhi, Sofiane Benmetir, Raad Nasrullah Salih, Haydar Mohammad‐Salim, Guy Y. S. Atohoun, Jesus Vicente de Julián‐Ortiz
Abstract
product has considerable binding affinity to the 1CIN protease, indicating its potential as a therapeutic inhibitor. Moreover, drug-likeness evaluations verified that the compounds adhere to Lipinski's rule of five, signifying advantageous pharmacokinetic characteristics.
Topics & Concepts
NitroneCycloadditionStereoselectivityPyrroleMechanism (biology)ChemistryStereochemistryMedicinal chemistryOrganic chemistryPhysicsCatalysisQuantum mechanicsOrganic Chemistry Cycloaddition ReactionsAdvanced Chemical Physics StudiesPorphyrin and Phthalocyanine Chemistry