Molecular regulatory mechanisms of erythropoiesis and related diseases
Lin Zhu, Chunyu He, Yuhao Guo, Huirong Liu, Suli Zhang
Abstract
The metabolism of cells and blood circulation allow for the constant production and destruction of red blood cells. Erythrocyte formation allows red blood cells to regenerate, which is crucial for maintaining the equilibrium of the organism. Erythrocyte formation is a multi-step, intricate process with distinct structural and functional characteristics at each stage. Erythropoiesis is regulated by a number of signaling pathways; malfunctional regulatory mechanisms may result in disease and aberrant erythropoiesis. Therefore, this article focuses on a review of the erythroid formation process, related signaling pathways, and red blood cell lineage diseases.
Topics & Concepts
ErythropoiesisRed blood cellBiologyCell biologyIneffective erythropoiesisSignal transductionBlood cellOrganismLineage (genetic)ImmunologyGeneticsAnemiaGeneMedicineInternal medicineErythrocyte Function and PathophysiologyHemoglobinopathies and Related DisordersBlood properties and coagulation