G2M checkpoint pathway alone is associated with drug response and survival among cell proliferation-related pathways in pancreatic cancer.
Masanori Oshi, Ankit Patel, Lan Le, Yoshihisa Tokumaru, Li Yan, Ryusei Matsuyama, Itaru Endo, Kazuaki Takabe
Abstract
= 0.03]). Among all six pathways, only G2M was consistently associated with worse patient survival in all three cohorts. In conclusion, each cell proliferation-related pathway was predictive of a unique agent, and the G2M score alone predicts survival in pancreatic cancer.
Topics & Concepts
Cancer researchPancreatic cancerCell growthDrugCancerMedicineOncologyBiologyPharmacologyInternal medicineGeneticsPancreatic and Hepatic Oncology ResearchEpigenetics and DNA MethylationCancer Genomics and Diagnostics