Olaparib Suppresses MDSC Recruitment via SDF1α/CXCR4 Axis to Improve the Anti-tumor Efficacy of CAR-T Cells on Breast Cancer in Mice
Ruixin Sun, Hong Luo, Su Jingwen, Shengmeng Di, Min Zhou, Bizhi Shi, Yansha Sun, Guoxiu Du, Honghong Zhang, Hua Jiang, Zonghai Li
Topics & Concepts
OlaparibBreast cancerCXCR4CancerCancer researchMedicineOncologyInternal medicineBiologyReceptorGeneChemokinePolymeraseBiochemistryPoly ADP ribose polymeraseCAR-T cell therapy researchPARP inhibition in cancer therapyToxin Mechanisms and Immunotoxins