Design and Identification of a GPR40 Full Agonist (<b>SCO-267</b>) Possessing a 2-Carbamoylphenyl Piperidine Moiety
Hideki Furukawa, Yasufumi Miyamoto, Yasuhiro Hirata, Koji Watanabe, Yuko Hitomi, Yayoi Yoshitomi, Jumpei Aida, Naoyoshi Noguchi, Nobuyuki Takakura, Kazuaki Takami, Seiji Miwatashi, Yoshihiko Hirozane, Teruki Hamada, Ryo Ito, Mitsugi Ookawara, Yusuke Moritoh, Masanori Watanabe, Tsuyoshi Maekawa
Abstract
) effectively stimulated insulin secretion and GLP-1 release and ameliorated glucose tolerance in diabetic rats via GPR40 full agonism.
Topics & Concepts
ChemistryFree fatty acid receptor 1PiperidineMoietyLipophilicityArylAgonistStereochemistryBenzamideIncretinInsulin analogAlkylReceptorInsulinBiochemistryOrganic chemistryInternal medicineEndocrinologyDiabetes mellitusType 2 diabetesHuman insulinMedicineDiabetes Treatment and ManagementReceptor Mechanisms and SignalingNeuropeptides and Animal Physiology