A hyper-fast gas chromatograph coupled to an ion mobility spectrometer with high repetition rate and flow-optimized ion source to resolve the short chromatographic peaks

Abstract

• Drift tube IMS with high repetition rate of 100 Hz to resolve gas chromatographic peaks with 100 ms full peak width at half peak maximum. • Hyper-fast GC-IMS with limits of detection in the low digit ppb v range and high IMS resolving power of R P = 60 at 120 °C. • Flow-optimized ion source with a minimum effective detector volume. By combining the high selectivity of a gas chromatograph (GC) with the high sensitivity and decent selectivity of an ion mobility spectrometer (IMS), GC-IMS have become increasingly popular in many applications. However, most GC suffer from long analysis times. In contrast, an hyper-fast GC allows for extremely fast analysis in the tens of seconds while reaching comparably high resolution. In turn, coupling such hyper-fast GC with IMS requires sufficiently high repetition rate of recording full IMS spectra to resolve the short GC peaks. Therefore, we present a drift tube IMS with 100 Hz repetition rate. Key is a small effective detector volume combined with short drift length. Therefore, the ion source of the IMS combines a small reaction region with an extended field-switching ion shutter and optimized gas flows. To resolve even the shortest GC peaks with a full width at half maximum of 100 ms, a short drift length of just 41 mm was used, achieving a measurement time of 10 ms per spectrum and hence ten data points across the shortest GC peak. To avoid condensation of the sample, the entire IMS was heated isothermally to 120 °C. Despite short drift times and high temperatures, the IMS still reaches high resolving power of R p = 60. The hyper-fast GC-IMS reaches low detection limits in the low ppb V range. For demonstration, ketone mixes and three different hop varieties were analyzed in <30 s.

Topics & Concepts