Immunotherapeutic IL-6R and targeting the MCT-1/IL-6/CXCL7/PD-L1 circuit prevent relapse and metastasis of triple-negative breast cancer
Aushia Tanzih Al Haq, Pao‐Pao Yang, Christopher Jin, Jou‐Ho Shih, Li‐Mei Chen, Hong‐Yu Tseng, Yen‐An Chen, Yueh‐Shan Weng, Lu‐Hai Wang, M Snyder, Hsin-Ling Hsu
Abstract
Systemic targeting the MCT-1/IL-6/IL-6R/CXCL7/PD-L1 interconnections enhances immune surveillance that inhibits the aggressiveness of TNBC.
Topics & Concepts
ImmunotherapyMedicineMetastasisCancer researchTriple-negative breast cancerFOXP3Breast cancerCancerOncologyInternal medicineImmunologyImmune systemCancer Immunotherapy and BiomarkersImmune cells in cancerImmunotherapy and Immune Responses