A biomimetic human disease model of bacterial keratitis using a cornea-on-a-chip system
Yudan Deng, Lingjun Li, Jianbin Xu, Yili Yao, Jiangtao Ding, Lei Wang, Chunxiong Luo, Wei Yang, Lingli Li
Abstract
This study presents a cornea-on-a-chip model for bacterial keratitis, elucidating antibiotic effectiveness in terms of bacterial eradication, cellular apoptosis reduction, and scar formation mitigation, offering new insights for ocular drug testing.
Topics & Concepts
CorneaKeratitisCorneal diseaseAntibioticsMicrobiologyMedicineBiologyOphthalmology3D Printing in Biomedical ResearchCell Image Analysis TechniquesNeuroscience and Neural Engineering