Polyisobutylene-based glycopolymers as potent inhibitors for <i>in vitro</i> insulin aggregation
Asmita Deka Dey, Ujjal Haldar, Tota Rajasekhar, Pooja Ghosh, Rudolf Faust, Priyadarsi De
Abstract
The Tyr fluorescence assay and NR fluorescence study revealed the crucial role of hydrophobic interaction in the inhibition process, whereas ITC measurements confirmed the importance of polar interaction. Thus, the block copolymers exhibit potent inhibition of insulin fibrillation owing to hydrophobic (from PIB segment) and glycosidic cluster effect (from sugar pendant block).
Topics & Concepts
CopolymerAmphiphileNile redChemistryRaftPolymer chemistryCationic polymerizationPolymerizationFluorescenceHydrophobic effectIsothermal titration calorimetryBiophysicsPolymerOrganic chemistryBiochemistryQuantum mechanicsPhysicsBiologyAdvanced Polymer Synthesis and CharacterizationMolecular Sensors and Ion Detectionbiodegradable polymer synthesis and properties