Lentinan-functionalized Selenium Nanoparticles target Tumor Cell Mitochondria via TLR4/TRAF3/MFN1 pathway
Huijuan Liu, Yuan Qin, Zihan Zhao, Yang Zhang, Jiahuan Yang, Denghui Zhai, Fang Cui, Ce Luo, Man-Xi Lu, Piao-Piao Liu, Hengwei Xu, Kun Li, Bo Sun, Shuang Chen, Honggang Zhou, Cheng Yang, Tao Sun
Abstract
Selene is a candidate anticancer drug for the treatment of malignant ascites. And TLR4/TRAF3/MFN1 may be a specific nano-drug delivery pathway that could target the mitochondria.
Topics & Concepts
MitochondrionMFN1ApoptosisEndocytosisCell biologyCancer researchBiologyCellChemistrymitochondrial fusionBiochemistryMitochondrial DNAGeneSelenium in Biological SystemsRedox biology and oxidative stressTrace Elements in Health