Design, synthesis and biological evaluation of brain penetrant benzazepine-based histone deacetylase 6 inhibitors for alleviating stroke-induced brain infarction
Zheng Guo, Zixue Zhang, Yi Zhang, Guan Wang, Ziyi Huang, Qinwei Zhang, Jianqi Li
Topics & Concepts
ChemistryBenzazepinePharmacologyHDAC6HDAC1Histone deacetylaseBiochemistryHistoneStereochemistryMedicineGeneHistone Deacetylase Inhibitors ResearchProtein Degradation and InhibitorsCholinesterase and Neurodegenerative Diseases