A single-cell analysis of the molecular lineage of chordate embryogenesis
Tengjiao Zhang, Yichi Xu, Kaoru S. Imai, Teng Fei, Guilin Wang, Bo Dong, Tianwei Yu, Yutaka Satou, Weiyang Shi, Zhirong Bao
Abstract
cell types can be matched to E6.5-E8.5 stage mouse cell types and display conserved expression of limited number of transcription factors. This study provides a high-resolution single-cell dataset to understand chordate early embryogenesis and cell lineage differentiation.
Topics & Concepts
ChordateLineage (genetic)Computational biologyBiologyCell lineageEvolutionary biologyEmbryogenesisCell biologyEmbryoCellular differentiationGeneticsGeneGenomeSingle-cell and spatial transcriptomicsCongenital heart defects researchPluripotent Stem Cells Research