Novel therapeutic heterocycles as selective cyclooxygenase-2 inhibitors and anti-cancer agents: Synthesis, in vitro bioassay screenings, and molecular docking studies
Musa I. El‐Barghouthi, Ayman S. Hasan, Wajdy Al‐Awaida, Hamzeh J. Al‐Ameer, Jatinder Kaur, Kaita J. Hayashibara, Jeremy Fleming, Jessica Waknin, Shigeo Hayashibara, Muna Slewa, Samer M. Hamzeh, Khaled Bodoor, Joshua Daniel McLoud, Frank Wuest, Baker Jawabrah Al Hourani
Topics & Concepts
ChemistryIC50Docking (animal)EnzymeCytotoxicityPharmacologyCyclooxygenaseTetrazolePotencyTyrosine kinaseIsozymeMTT assayEnzyme inhibitorStereochemistryBiochemistryIn vitroReceptorNursingMedicineSynthesis and biological activityInflammatory mediators and NSAID effectsSynthesis of Tetrazole Derivatives