Radioiodination and biological evaluation of Cimetidine as a new highly selective radiotracer for peptic ulcer disorder detection
M. H. Sanad, Safaa B. Challan, F. A. Marzook, S. M. Abd-Elhaliem, Ebtisam A. Marzook
Abstract
Abstract One of the most famous techniques for stomach ulcer imaging is the nuclear imaging technique. We aim to focus on the synthesis of 125 I-cimetidine ( 125 I-cim) as an agent for peptic ulcer imaging. Cimetidine was labeled with Iodine-125 using a different oxidizing agent (Ch-T, NBS). All factors affecting the labeling yield were optimized. The radiochemical yield of 125 I-cim was 98 ± 0.22% at optimum conditions. In vitro stability, in vivo biodistribution of 125 I-cimetidine was studied in three groups: control group, pretreated group, and ulcer bearing group. In vivo biodistribution studies of 125 I-cim revealed high uptake in the stomach ulcer, reaching about 75.4 ± 1.2% ID/g at 15 min post-injection, than pretreated groups compared to the control. The results showed the suitability of using 125 I-cimetidine for stomach ulcer imaging.