Quercetin inhibits hepatotoxic effects by reducing trimethylamine-<i>N</i>-oxide formation in C57BL/6J mice fed with a high <scp>l</scp>-carnitine diet
Li Zhang, Qiu Wu, Nan Wang, Liansheng Zhang, Xingbin Yang, Yan Zhao
Abstract
Quercetin could attenuate the hepatotoxic effects of the mice fed with a high l -carnitine diet via inhibiting the circulating trimethylamine N -oxide (TMAO) formation.
Topics & Concepts
QuercetinCarnitineTrimethylamine N-oxideChemistryTrimethylamineAntioxidantDyslipidemiaPharmacologyToxicityLiver injuryEndocrinologyBiochemistryInternal medicineMedicineOrganic chemistryObesityDiet and metabolism studiesMetabolomics and Mass Spectrometry StudiesMetabolism and Genetic Disorders