Converting cell death into senescence by PARP1 inhibition improves recovery from acute oxidative injury
Jamil Nehme, Lina Mesilmany, Marta Varela-Eirín, Simone Brandenburg, Abdullah Altulea, Yao Lin, Mariana Gaya da Costa, Marc A. Seelen, Jan‐Luuk Hillebrands, Harry van Goor, Raya Saab, Haidar Akl, Natalia Prevarskaya, Valério Farfariello, Marco Demaria
Topics & Concepts
SenescenceProgrammed cell deathOxidative stressPARP1Cell biologyPoly ADP ribose polymeraseMitochondrionApoptosisBiologyReactive oxygen speciesCellNecrosisCancer researchPolymeraseBiochemistryGeneticsGeneTelomeres, Telomerase, and SenescencePARP inhibition in cancer therapyCell death mechanisms and regulation