The Parkinson’s disease-associated mutation LRRK2 G2385R alters mitochondrial biogenesis via the PGC-1α-TFAM pathway
Jian Xue, Jinbao Zhang, Jinru Zhang, Junyi Liu, Fen Wang, Kai Li, Chun‐Feng Liu, Chun‐Feng Liu
Topics & Concepts
LRRK2TFAMMitochondrial biogenesisBiologyMitochondrionMutationMitochondrial DNAmitochondrial fusionSignal transductionGeneticsCell biologyGeneMitochondrial Function and PathologyParkinson's Disease Mechanisms and TreatmentsCoenzyme Q10 studies and effects