Integrin Subtypes and Nanoscale Ligand Presentation Influence Drug Sensitivity in Cancer Cells
Jennifer L. Young, Ximeng Hua, Heidi Somsel, Florian Reichart, Horst Kessler, Joachim P. Spatz
Abstract
on fibronectin; however, this is heavily reliant on nanoscale spacing, as the opposite is observed when ligands are spaced at 70 nm. These data imply that even nanoscale alterations in extracellular matrix properties have profound effects on cancer cell survival and can thus inform future therapies and drug testing platforms.
Topics & Concepts
IntegrinFibronectinLigand (biochemistry)Cell adhesionExtracellular matrixCancer cellAdhesionChemistryBiophysicsFocal adhesionPeptidomimeticCancer researchNanotechnologyCell biologyCancerMaterials scienceCellBiologyBiochemistryPeptideReceptorGeneticsOrganic chemistryCell Adhesion Molecules ResearchCellular Mechanics and InteractionsNanofabrication and Lithography Techniques