Fatty acid metabolism in adaptive immunity
Xian Zhou, Xingxing Zhu, Hu Zeng
Abstract
Fatty acids (FAs) not only are a key component of cellular membrane structure, but also have diverse functions in biological processes. Recent years have seen great advances in understanding of how FA metabolism contributes to adaptive immune response. Here, we review three key processes, FA biosynthesis, FA oxidation and FA uptake, and how they direct T and B cell functions during immune challenges. Then, we will focus on the relationship between microbiota derived FAs, short-chain FAs, and adaptive immunity. Along the way, we will also discuss the outstanding controversies and challenges in the field.
Topics & Concepts
Immune systemAcquired immune systemImmunityBiologyMetabolismFatty acid metabolismComputational biologyBiochemistryFatty acidCell metabolismCell biologyChemistryImmunologyImmune Cell Function and InteractionImmune cells in cancerPeroxisome Proliferator-Activated Receptors