Senescence and Cancer: Role of Nitric Oxide (NO) in SASP
Nesrine Mabrouk, S Ghione, Véronique Laurens, Stéphanie Plenchette, Ali Bettaı̈eb, Catherine Paul
Abstract
Cellular senescence is a cell state involved in both physiological and pathological processes such as age-related diseases and cancer. While the mechanism of senescence is now well known, its role in tumorigenesis still remains very controversial. The positive and negative effects of senescence on tumorigenesis depend largely on the diversity of the senescent phenotypes and, more precisely, on the senescence-associated secretory phenotype (SASP). In this review, we discuss the modulatory effect of nitric oxide (NO) in SASP and the possible benefits of the use of NO donors or iNOS inducers in combination with senotherapy in cancer treatment.
Topics & Concepts
SenescenceCarcinogenesisNitric oxidePhenotypeCancerCellular senescenceMechanism (biology)Cancer researchPathologicalBiologyAgeingCell biologyImmunologyMedicineBiochemistryGeneticsPathologyEndocrinologyPhilosophyGeneEpistemologyTelomeres, Telomerase, and SenescenceNeutrophil, Myeloperoxidase and Oxidative MechanismsNanoplatforms for cancer theranostics