Highly Antiproliferative Latonduine and Indolo[2,3-<i>c</i>]quinoline Derivatives: Complex Formation with Copper(II) Markedly Changes the Kinase Inhibitory Profile
Christopher Wittmann, Felix Bacher, Éva A. Enyedy, Orsolya Dömötör, Gabriella Spengler, Christian Madejski, Jóhannes Reynisson, Vladimir B. Arion
Abstract
revealed strong inhibition of five other enzymes, i.e., SGK-1, PKA, CaMK-1, GSK3β, and MSK1, from a panel of 50 kinases. Furthermore, molecular modeling of the ligands and complexes showed a good fit to the binding pockets of these targets.
Topics & Concepts
ChemistryQuinolineCopperStereochemistryEnzymeKinaseIC50Bioinorganic chemistryBiochemistryIn vitroOrganic chemistryCancer Mechanisms and TherapyCancer therapeutics and mechanismsSynthesis and bioactivity of alkaloids