Cohort profile: the ESC EURObservational Research Programme Non-ST-segment elevation myocardial infraction (NSTEMI) Registry
Ramesh Nadarajah, Peter Ludman, Yolande Appelman, Salvatore Brugaletta, Andrzej Budaj, Hector Bueno, Kurt Huber, Vijay Kunadian, Sergio Leonardi, Maddalena Lettino, Dejan Milašinović, C P Gale, the NSTEMI Investigators, Alec Vahanian, Andrzej Budaj, N. Dagres, Nicolas Danchin, Victoria Delgado, Jonathan Emberson, Örjan Friberg, Chris P Gale, Guy R. Heyndrickx, Bernard Iung, Stefan James, A P Kappetein, A P Maggioni, Nikos Maniadakis, K V Nagy, G Parati, A-S Petronio, Mikko Pietilä, E Prescott, Frank Ruschitzka, Frans Van de Werf, Franz Weidinger, Uwe Zeymer, Chris P Gale, B Beleslin, Andrzej Budaj, Ovidiu Chioncel, N. Dagres, Nicolas Danchin, Jonathan Emberson, David Erlinge, M Glikson, A Gray, M Kayikcioglu, Aldo P. Maggioni, K V Nagy, A Nedoshivin, A-P Petronio, J W Roos-Hesselink, L Wallentin, Uwe Zeymer, Bogdan A. Popescu, David Adlam, Alida L.P. Caforio, D Capodanno, Marc R. Dweck, David Erlinge, M Glikson, J Hausleiter, Bernard Iung, M Kayikcioglu, Peter Ludman, Lars H. Lund, A P Maggioni, С.Т. Мацкеплишвили, Benjamin Meder, Klaudia Vivien Nagy, A Nedoshivin, Carlijn G. E. Thijssen, Agnès Pasquet, J W Roos-Hesselink, Fernando J. Rossello, Sameh Shaheen, Aleksandra Torbica, Chris P Gale, Peter Ludman, Maddalena Lettino, Hector Bueno, Kurt Huber, Sergio Leonardi, Andrzej Budaj, Dejan Milašinović, Salvatore Brugaletta, Yolande Appelman, Vijay Kunadian, W A R Al Mahmeed, H Kzhdryan, Carlos Dumont, Alexander Geppert, Nirvana Šabanović-Bajramović, Fathima Aaysha Cader, Christophe Beauloye, Daniel Quesada, Ota Hlinomaz, Christoph Liebetrau, Toomas Marandi, Khaled Shokry
Abstract
AIMS: The European Society of Cardiology (ESC) EURObservational Research Programme (EORP) Non-ST-segment elevation myocardial infarction (NSTEMI) Registry aims to identify international patterns in NSTEMI management in clinical practice and outcomes against the 2015 ESC Guidelines for the management of acute coronary syndromes in patients presenting without ST-segment-elevation. METHODS AND RESULTS: Consecutively hospitalised adult NSTEMI patients (n = 3620) were enrolled between 11 March 2019 and 6 March 2021, and individual patient data prospectively collected at 287 centres in 59 participating countries during a two-week enrolment period per centre. The registry collected data relating to baseline characteristics, major outcomes (in-hospital death, acute heart failure, cardiogenic shock, bleeding, stroke/transient ischaemic attack, and 30-day mortality) and guideline-recommended NSTEMI care interventions: electrocardiogram pre- or in-hospital, pre-hospitalization receipt of aspirin, echocardiography, coronary angiography, referral to cardiac rehabilitation, smoking cessation advice, dietary advice, and prescription on discharge of aspirin, P2Y12 inhibition, angiotensin converting enzyme inhibitor (ACEi)/angiotensin receptor blocker (ARB), beta-blocker, and statin. CONCLUSION: The EORP NSTEMI Registry is an international, prospective registry of care and outcomes of patients treated for NSTEMI, which will provide unique insights into the contemporary management of hospitalised NSTEMI patients, compliance with ESC 2015 NSTEMI Guidelines, and identify potential barriers to optimal management of this common clinical presentation associated with significant morbidity and mortality.