Tead1 is essential for mitochondrial function in cardiomyocytes
Ruya Liu, Rajaganapathi Jagannathan, Lingfei Sun, Feng Li, Ping Yang, Jeongkyung Lee, Vinny Negi, Eliana Melissa Perez-Garcia, Sruti Shiva, Vijay Yechoor, Mousumi Moulik
Abstract
Mitochondrial dysfunction constitutes an important aspect of heart failure etiopathogenesis and progression. However, the molecular mechanisms are still largely unknown. Growing lines of evidence indicate that Hippo-Tead pathway plays a role in cellular bioenergetics. This study reveals the novel role of Tead1, the downstream transcriptional effector of Hippo pathway, as a novel regulator of mitochondrial oxidative phosphorylation and in vivo cardiomyocyte energy metabolism, thus providing a potential therapeutic target for modulating mitochondrial function and enhancing cytoprotection of cardiomyocytes.