Ubiquitin-specific Protease 35 Promotes Gastric Cancer Metastasis by Increasing the Stability of Snail1
Cunying Ma, Zhuangfei Tian, Dandan Wang, Wenrong Gao, Lilin Qian, Yichen Zang, Xia Xu, Jihui Jia, Zhifang Liu
Abstract
infection increased USP35 and Snail1 expression levels. Altogether, we found that USP35 can deubiquitinate Snail1 and increase its expression, thereby contributing to the malignant progression of GC. Therefore, USP35 may serve as a viable target for GC treatment.
Topics & Concepts
Deubiquitinating enzymeGene knockdownUbiquitinEpithelial–mesenchymal transitionBiologyCancer researchCarcinogenesisCancerProteasesMesenchymal stem cellTranscription factorCancer cellMetastasisMolecular biologyCell cultureGeneCell biologyGeneticsEnzymeBiochemistryUbiquitin and proteasome pathwaysEpigenetics and DNA MethylationFerroptosis and cancer prognosis