Chimeric Phage Nanoparticles for Rapid Characterization of Bacterial Pathogens: Detection in Complex Biological Samples and Determination of Antibiotic Sensitivity
Huan Peng, Raymond E. Borg, Anna Nguyen, Irene A. Chen
Abstract
infection). We also show that this assay can be used to identify the antibiotic susceptibility profile based on detection of bacterial growth in the presence of different antibiotics. The prospect for using phage-conjugated AuNPs to detect bacterial pathogens in clinical samples and guide antibiotic choice is discussed.
Topics & Concepts
AntibioticsMicrobiologyPseudomonas aeruginosaBacteriaPhage therapyBiologyEscherichia coliPathogenic bacteriaVibrio choleraeAntibiotic resistanceBacteriophageGeneBiochemistryGeneticsBacteriophages and microbial interactionsBiosensors and Analytical DetectionBacterial Identification and Susceptibility Testing