Caspase-mediated AURKA cleavage at Asp<sup>132</sup> is essential for paclitaxel to elicit cell apoptosis
Xiaoting Chen, Shujuan Du, Yulin Zhang, Ke Peng, L.-Y. Liu, Ting Ting Wang, Hao Zhang, Shen Cai, Caixia Zhu, Youhai Li, Wen Tuo, Yuyan Wang, Wei Fang, Qiliang Cai
Abstract
is a potential key target for chemotherapy.
Topics & Concepts
ApoptosisPaclitaxelCleavage (geology)Cell biologyChemistryCellCaspase 3CaspaseCancer researchProgrammed cell deathBiologyBiochemistryCancerGeneticsPaleontologyFracture (geology)Cancer Treatment and PharmacologyLung Cancer Treatments and MutationsMicrotubule and mitosis dynamics