Optimized L-SNEDDS and spray-dried S-SNEDDS using a linked QbD-DM3 rational design for model compound ketoprofen
Vivek D. Patel, Vishal Rathod, Rahul V. Haware, William C. Stagner
Topics & Concepts
KetoprofenChromatographySolubilityDispersityDissolutionChemistryDrug deliverySpray dryingBox–Behnken designMicronizationGranulationParticle sizeMaterials scienceResponse surface methodologyOrganic chemistryComposite materialPhysical chemistryDrug Solubulity and Delivery SystemsAnalytical Chemistry and ChromatographyAdvanced Drug Delivery Systems