Optimization and sustainability assessment of a continuous flow Ru-catalyzed ester hydrogenation for an important precursor of a β2-adrenergic receptor agonist
Michael Prieschl, Jorge García‐Lacuna, Rachel H. Munday, Kevin Leslie, Anne O’Kearney-McMullan, Christopher A. Hone, C. Oliver Kappe
Abstract
The development of a continuous flow ruthenium-catalyzed ester reduction using hydrogen gas is described. The assessment of green metrics show the protocol is substantially more sustainable than commonly employed metal hydride reductions.
Topics & Concepts
RutheniumAgonistCatalysisHydrideChemistryHydrogenAdrenergic receptorMetalContinuous flowCombinatorial chemistryOrganic chemistryReceptorBiochemistryBiochemical engineeringEngineeringInnovative Microfluidic and Catalytic Techniques InnovationAsymmetric Hydrogenation and CatalysisChemistry and Chemical Engineering