The Potential Roles of Glial Cells in the Neuropathogenesis of Cerebral Malaria
Nana Efua Andoh, Ben Gyan
Abstract
parasite. It is one of the leading causes of death in children under 5 years of age in Sub-Saharan Africa. CM is associated with blood-brain barrier disruption and long-term neurological sequelae in survivors of CM. Despite the vast amount of research on cerebral malaria, the cause of neurological sequelae observed in CM patients is poorly understood. In this article, the potential roles of glial cells, astrocytes, and microglia, in cerebral malaria pathogenesis are reviewed. The possible mechanisms by which glial cells contribute to neurological damage in CM patients are also examined.
Topics & Concepts
Cerebral MalariaMalariaMicrogliaPathogenesisMedicinePlasmodium falciparumBrain damageImmunologyNeurosciencePathologyBiologyInflammationNeuroinflammation and Neurodegeneration MechanismsMalaria Research and ControlCalpain Protease Function and Regulation