Advanced hybrid silica nanoparticles with pH-responsive diblock copolymer brushes: optimized design for controlled doxorubicin loading and release in cancer therapy
Shatha Lahmadi, Salman Alamery, Abeer M. Beagan, Khalid M. Alotaibi, Abdullah M. Alswieleh
Abstract
loading capacity. Cytotoxicity assays on Caco2 colon cancer cells revealed that unloaded nano-systems, at concentrations above 45 μM, resulted in approximately 60% cell death, indicating inherent anti-cancer properties. However, variations in cytotoxic effects were observed in drug-loaded MSNs, with some modifications showing reduced anti-cancer activity. These findings highlight the potential of MSNs in drug delivery and cancer treatment, emphasizing the importance of nanoparticle design in therapeutic efficacy.
Topics & Concepts
CopolymerDoxorubicinMaterials scienceNanoparticleChemical engineeringNanotechnologyPolymerComposite materialChemotherapyEngineeringMedicineSurgeryPolymer Surface Interaction StudiesNanoparticle-Based Drug DeliveryDendrimers and Hyperbranched Polymers