Proteasomal degradation of the intrinsically disordered protein tau at single-residue resolution
Tina Ukmar, Pan Fang, Alain Ibáñez de Opakua, F. Henneberg, Aljaž Godec, Kuan‐Ting Pan, Maria‐Sol Cima‐Omori, Ashwin Chari, Eckhard Mandelkow�, Henning Urlaub, Markus Zweckstetter
Abstract
proteasome, the residue specificity of degradation, single-residue degradation kinetics, and their regulation by posttranslational modification.
Topics & Concepts
ProteasomePhosphorylationProteolysisIntrinsically disordered proteinsUbiquitinChemistryTau proteinResidue (chemistry)Protein degradationBiochemistryKinaseKineticsCleavage (geology)Cell biologyBiologyEnzymeAlzheimer's diseaseDiseaseMedicineGenePaleontologyPathologyPhysicsQuantum mechanicsFracture (geology)Ubiquitin and proteasome pathwaysAutophagy in Disease and TherapyAlzheimer's disease research and treatments