TBK1 phosphorylates mutant Huntingtin and suppresses its aggregation and toxicity in Huntington's disease models
Ramanath Narayana Hegde, Anass Chiki, Lara Petricca, Paola Martufi, Nicolas Arbez, Laurent Mouchiroud, Johan Auwerx, Christian Landles, Gillian P. Bates, Malvindar K. Singh‐Bains, Mike Dragunow, Maurice A. Curtis, Richard L. M. Faull, Christopher A. Ross, Andrea Caricasole, Hilal A. Lashuel
Topics & Concepts
HuntingtinPhosphorylationMutantCell biologyKinaseChemistryHuntingtin ProteinBiologyMolecular biologyBiochemistryGeneGenetic Neurodegenerative DiseasesMitochondrial Function and PathologyMuscle Physiology and Disorders