Highly stereoselective α-glycosylation with GalN <sub>3</sub> donors enabled collective synthesis of mucin-related tumor associated carbohydrate antigens
Kunxiu Shou, Yunqin Zhang, Yujie Ji, Bin Liu, Qingli Zhou, Qiang Tan, Fuying Li, Xiufang Wang, Gang Lü, Guozhi Xiao
Abstract
Collective synthesis of mucin-related tumor associated carbohydrate antigens has been achieved via this new α-glycosylation method with GalN 3 donors, which features mild conditions, broad substrate scope, high yields and stereoselectivities.
Topics & Concepts
GlycosylationStereoselectivityMucinChemistryAntigenComputational biologyBiochemistryCatalysisBiologyImmunologyCarbohydrate Chemistry and SynthesisGlycosylation and Glycoproteins ResearchChemical Synthesis and Analysis