Aceclofenac-induced hepatotoxicity: An ameliorative effect of<i>Terminalia bellirica</i>fruit and ellagic acid
Ashutosh Gupta, Abhay K. Pandey
Abstract
BACKGROUND: fruit extracts and its phytoconstituent ellagic acid (EA) are expected to provide protection against oxidative stress and liver damage produced by long-term use of ACF. AIM: fruit extracts and EA against ACF-induced toxicity in albino Wistar rats. METHODS: extracts (200 mg/kg) and EA (40 mg/kg) in ACF-induced hepatotoxic rats were assessed in serum and liver tissue after oral administration for 21 d. Silymarin (40 mg/kg) was used as a standard control. Oxidative stress markers in the blood (ferric reducing ability of plasma and lipid peroxidation inhibition) and liver tissues (superoxide dismutase, catalase and malondialdehyde) were analyzed using standard protocols. Liver function markers such as alkaline phosphatase, glutamic pyruvic transaminase, glutamic oxaloacetic transaminase, lactate dehydrogenase, γ-glutamyl transferase, creatinine, total protein, and uric acid were evaluated in rat serum. RESULTS: fruit extracts. Of these extracts, ethyl acetate extract revealed comparatively better antioxidant and hepatoprotective activity. CONCLUSION: fruit extracts exhibited considerable hepatoprotective and antioxidant activities in long-term ACF-treated rats.