Elemental‐Sulfur‐Enabled Divergent Synthesis of Disulfides, Diselenides, and Polythiophenes from β‐CF<sub>3</sub>‐1,3‐Enynes
Shengnan Jin, Shijun Li, Xingxing Ma, Jianke Su, Haohua Chen, Yu Lan, Qiuling Song
Abstract
Abstract Divergent synthesis for precise constructions of cyclic unsymmetrical diaryl disulfides or diselenides and polythiophenes from CF 3 ‐containing 1,3‐enynes and S 8 was developed when the ortho group is F, Cl, Br, and NO 2 on aromatic rings. Meanwhile, disulfides (diselenides) were also quickly constructed when the ortho group is H. These transformations undergo cascade thiophene construction/selective C3‐position thiolation process, featuring simple operations, divergent synthesis, broad substrate scope, readily available starting materials, and valuable products. A novel plausible radical annulation process was proposed and validated by DFT calculations for the first time. A series of derivatizations about the thiophene (TBT) and disulfides were also well‐represented.